A squad of 26 players make the journey to the base in Troia, some 35 miles south of Lisbon.
Paco Herrera, Blues new Assistant Head Coach, accompanies Pep Clotet's side as they fly from Birmingham Airport.
Maikel Kieftenbeld travels with the group as he continues his rehabilitation from a serious knee injury. Blues did similar last year with Isaac Vassell.
And Blues add UE Cornella players Ivan Guzman and Agustin Medina to the squad, both of whom have been training with Blues during pre-season at the Trillion Trophy Training Centre, Wast Hills.
Guzman is a 28-year-old forward and Medina a 24-year-old midfielder.
Jacques Maghoma is not in the group due to his involvement in the Africa Cup of Nations, while Blues Under-23s captain Geraldo Bajrami remains on the way back after a hernia operation.
Blues staged an internal game at the training ground on Friday, with First Team taking on the Under-23s, as a precursor to Portugal.
Blues will be put through their paces at the One Troia Jose Mourinho Training Centre, a purpose-built complex they have to themselves for the stay.
And the squad will take part in a three-team tournament, in Setubal.
They will face CD Cova Piedade in the opening match of the Torneio Internacional Do Sado at the Estádio do Bonfim (8pm) on Thursday.
Host side Vitoria Setubal then face CD Cova Piedade the next day at 8pm.
Then Blues take on Setubal on Saturday in the tournament closer at the Estádio do Bonfim (6pm).
Squad: Lee Camp, Connal Trueman, David Stockdale, Maxime Colin, Josh Dacres-Cogley, Wes Harding, Kristian Pedersen, Jonathan Grounds, Steve Seddon, Cheick Keita, Harlee Dean, Marc Roberts, Joe Redmond, Corey O'Keeffe, Maikel Kieftenbeld, Agustin Medina, Charlie Lakin, Gary Gardner, Craig Gardner, David Davis, Jude Bellingham, Kerim Mrabti, Isaac Vassell, Odin Bailey, Lukas Jutkiewicz, Ivan Guzman.