The fixture is being played at Nuneaton Town's Liberty Way ground (12 noon kick-off).
And it promises to be an interesting climax in the battle to join Reading, who are group winners, in the knockout stage.
Two hours after Blues match, the other challengers Fulham entertain Reading in their last outing.
Fulham currently hold second spot with nine points, and a goal difference of nine, largely thanks to their 5-0 victory at Colchester last week.
Blues are third on seven points (goal difference one) so need victory on Friday and hope the result goes their way at Motspur Park.
Blues are again without Kyle McFarlane, due to a knee injury. He is expected to be fit mid-March. And Ryan Burke (thigh) is also sidelined. Beryly Lubala (hamstring) got injured in Blues last Under-23s match.
Ryan Stirk, George Baker and Ben Forrest return to the squad after Blues went with several first teamers last time out, in order to boost their minutes in action. Adam Siviter, Kieron Dawes, Ben McLean and Kane Thompson-Sommers have been drafted up again.
Admission is free to Blues Season Ticket Holders and Loyalty Members, otherwise £4 and £2.
Blues (from): Siviter, Jeacock, Hutton, Dawes, Forrest, Redmond, Bajrami, Stirk, O'Keeffe, McLean, Thompson-Sommers, Baker, Boyd-Munce, Andrews, Bailey, McCoy.