Carla Ward made two changes to the side that drew Wednesday's Second City derby.BCFC
Goals from Esme Morgan, Sam Mewis and a brace from Chloe Kelly gave the hosts the victory.
Hannah Hampton put in fine performance, making several stops to deny the home team from adding to their lead, including a penalty save to deny Caroline Weir.
Carla Ward made two changes to the side that drew Wednesday's Second City derby. Emily Murphy and Lucy Whipp came in for the injured Ruesha Littlejohn and Sarah Mayling.
Manchester City started brightly and Hampton was called into action inside the first minute, with the ‘keeper getting down well to push Kelly’s effort away from goal.
The forward, unfortunately, did not miss with her second chance. Weir’s initial effort was saved by Hampton, but Kelly reacted quickest to tap into an empty net.
Midway through the half, the hosts doubled their advantage. Lauren Hemp burst down the left-hand side and fired a cross into the middle where Kelly was waiting to guide in her second of the game.
Half-Time: Manchester City 2 Blues Women 0
Blues began to frustrate the hosts in the opening minutes of the second-half, with the Citizens failing to create any clear-cut openings.
Entering the final 20 minutes, the home side were awarded a penalty after Rebecca Holloway was adjudged to have fouled Kelly.
After a long delay Weir stepped up, but Hampton got down well to deny the Scottish midfielder from the spot.
Hampton was again called into action to deny the Scot, this time diving to her left to stop Gareth Taylor's players from adding another.
However, City got their third heading into the closing stages. A low corner was not fully dealt with and Morgan reacted to prod it in.
The home side rounded off the scoring with their fourth in injury time. American Mewis fired in from a corner.
Manchester City: Ellie Roebuck, Lucy Bronze, Esme Morgan, Alex Greenwood, Georgia Stanway, Keira Walsh, Laura Coombs (Sam Mewis 78), Caroline Weir, Chloe Kelly (Janine Beckie 73), Lauren Hemp (Jess Park 87), Ellen White (Rose Lavelle 78).
Substitutes not used: Karima Benameur, Abby Dahlkemper, Millie Davies, Aoife Mannion.
Blues Women: Hannah Hampton, Emma Kelly, Georgia Brougham, Harriet Scott, Ruby Mace, Rebecca Holloway, Emily Murphy (Mollie Green 57), Christie Murray, Lucy Whipp, Jamie-Lee Napier, Claudia Walker.
Substitutes not used: Sophie Whitehouse, Veatriki Sarri, Heidi Logan.
Referee: Emily Heaslip